S100+ cells: A new neuro-immune cross-talkers in lymph organs
نویسندگان
چکیده
Up to now, the 'hardwired' neural pathway of the neuro-immune regulation is not fully understood. Here we reported a new neural pathway which links sympathetic nerves with immune cells of the lymphoid tissues. Our results demonstrated that nerve fibers derived from superior cervical ganglion directly targeted only S100(+) cells in the cervical lymph nodes. Moreover, we found co-expression of neurotransmitters such as norepinephrine, vasoactive intestinal polypeptide and neuropeptide Y in the postganglionic sympathetic nerve endings that innervate S100(+) cells. Our findings suggested that S100(+) cells serve as a neuro-immune cross-talker in lymph organs that may play a significant role in transmitting signals of nervous cells to targeted immune cells. The new findings provide better understanding of the cross-talk mechanism between the nervous system and the immune system.
منابع مشابه
Metastatic cutaneous neuro- myofibroblastic sarcoma induced by avian leukosis virus subgroup J in a rooster (Gallus gallus domesticus)
An adult native cock (Gallus gallus domesticus) referred to the aviary clinic with multiple different sizes of round dermal nodules. The bird died few days later, and was then submitted for further evaluation. Macroscopic and microscopic examinations as well as a PCR test were done to identify type and cause of the tumor. In histopathological assessment of biopsy specimen, it consisted of inter...
متن کاملMesenchymal cell differentiation during lymph node organogenesis
Secondary lymphoid tissues such as lymph nodes are essential for the interactions between antigen presenting cells and lymphocytes that result in adaptive immune responses that protect the host against invading pathogens. The specialized architecture of these organs facilitates the cognate interactions between antigen-loaded dendritic cells and lymphocytes expressing their specific receptor as ...
متن کاملO22: Principles of Treatment in Neuro-Inflammation Disorders
Treating Central Nervous System (CNS) neuro-inflammational disorders is of great importance. A key aspect of this treatment includes regulation of Cell-Mediated and humoral immune systems. Previous treatment mostly consisted of systemic immunosuppressive drugs. In addition to having adverse side effects, these drugs were also inefficient, such as methotrexate- Cyclophosphamide-Azathioprine. Rec...
متن کاملSchwannoma In A Perigastric Lymph Node: A Rare Case Report
Schwannomas are benign nerve sheath tumors that originate from any anatomical site. Most of the schwannomas are found in the head, neck or limbs. Schwannoma arising in a lymph node is extremely rare. We have found only four cases in the review of the literature. We experienced a case of intranodal schwannoma in a perigastric lymph node. A 72 year-old female underwent cholecystectomy due to ...
متن کاملPenile fibrosarcoma tumor in a bull
This is a report of a penile fibrosarcoma in a two-year-old crossbred Holstein bull. The ulcerated tumormass with dimensions of 7 × 9 × 6.5 cm, was enveloped the glans and body of the penis. It had a white-graycolor at cross section appearance. There was no metastatic evidence of regional lymph node enlargement.Histopathologically, elongated spindle-shaped cells arranged densely in the interwov...
متن کامل